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Article

Repurposing statin treatment for the prevention of gallstone disease.

Atherosclerosis - 1 Oct 2025

Rønborg Søren N, Qayyum Faiza, Lauridsen Bo K, Frikke-Schmidt Ruth, Nordestgaard Børge G, Christoffersen Mette, Tybjærg-Hansen Anne

Abstract excerpt

BACKGROUND AND AIMS: In observational studies, statin treatment has been associated with low risk of gallstone disease (GSD) or cholecystectomy. We tested the hypothesis that genetic variation in HMGCR, mimicking statin treatment, causally lowers risk of GSD and cholecystectomy in the general population. METHODS: A drug-target Mendelian randomization analysis was conducted using individual participant data on...

Read the complete abstract on PubMed

Topics

Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Gallstones
Mendelian Randomization Analysis
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Cholecystectomy

Drug Repositioning

Denmark

Cholesterol, LDL

Hydroxymethylglutaryl CoA Reductases

Adult

Aged

Risk Factors

Polymorphism, Single Nucleotide

Treatment Outcome

Genetic Predisposition to Disease

Source

Identifiers

PMID: 40934790
DOI: 10.1016/j.atherosclerosis.2025.120507

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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