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Article

Association of HMGCR rs17671591 and rs3761740 with lipidemia and statin response in Uyghurs and Han Chinese.

PeerJ - 1 Jan 2024

Liu Ziyang, Zhou Yang, Jin Menglong, Liu Shuai, Liu Sen, Yang Kai, Li Huayin, Luo Sifu, Jureti Subinuer, Wei Mengwei, Fu Zhenyan

Abstract excerpt

Background: Dyslipidemia plays a very important role in the occurrence and development of cardiovascular disease (CVD). Genetic factors, including single nucleotide polymorphisms (SNPs), are one of the main risks of dyslipidemia. 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is not only the rate-limiting enzyme step of endogenous cholesterol production, but also the therapeutic target of statins. Methods: We...

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Source

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Identifiers

PMID: 39351366
DOI: 10.7717/peerj.18144
PMCID: PMC11441381

Genes

HMGCR
APOB
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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