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Article

Serum urate, cardiovascular mediators, and atrial fibrillation: genetic evidence for URAT1-targeted therapy.

Clinical rheumatology - 1 Feb 2026

Lin Chaoyang, Lai Qianyao, Fang Enze, Luo Ben, Chen Zhiwei, Huang Jinhua, Hu Feng, Yao Enhui

Abstract excerpt

BACKGROUND: Current evidence indicates that high serum urate levels are associated with an increased occurrence of atrial fibrillation (AF), and urate-lowering drugs could potentially reduce this risk. Nonetheless, the processes driving this relationship remain unclear. OBJECTIVE: To identify key mediators linking urate to AF and assess the direct effects of potential drug targets on AF risk. METHODS: Genetic...

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PMID: 41369868
DOI: 10.1007/s10067-025-07827-9

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