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Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study

18 Oct 2019

Abstract excerpt

BACKGROUND: The role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance. METHODS AND FINDINGS: A phenome-wide association study (PheWAS) together with a Bayesian analysis of tree-structured phenotypic model (TreeWAS) was performed to examine disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31626644
DOI: 10.1371/journal.pmed.1002937

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