Article
Serum uric acid, body mass index, and cardiovascular diseases: A multiple two-step Mendelian randomization study.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Oct 2024
Chen Xiaohan, Cheng Siyuan, Huang Lei, Chen Xudong, Jin Nake, Hong Jun, Zhao Xuechen, Rong Jiacheng
Abstract excerpt
BACKGROUND AND AIMS: A number of health issues, including high serum uric acid (SUA) and cardiovascular disease (CVD), have been linked to obesity based on observational evidence, though it's currently unclear how these issues are causally related. In order to determine whether obesity mediates this association, we set out to investigate the causal relationship between SUA, obesity, and CVD. METHODS AND RESULTS:...
Topics
- Humans
- Mendelian Randomization Analysis
- Body Mass Index
- Uric Acid
- Cardiovascular Diseases
- Obesity
- Genome-Wide Association Study
- Risk Assessment
- Biomarkers
- Hyperuricemia