Article
Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2021
Gill Dipender, Cameron Alan C, Burgess Stephen, Li Xue, Doherty Daniel J, Karhunen Ville, Abdul-Rahim Azmil H, Taylor-Rowan Martin, Zuber Verena, Tsao Philip S, Klarin Derek, Evangelou Evangelos, Elliott Paul, Damrauer Scott M, Quinn Terence J, Dehghan Abbas, Theodoratou Evropi, Dawson Jesse, Tzoulaki Ioanna
Abstract excerpt
Serum urate has been implicated in hypertension and cardiovascular disease, but it is not known whether it is exerting a causal effect. To investigate this, we performed Mendelian randomization analysis using data from UK Biobank, Million Veterans Program and genome-wide association study consortia, and meta-analysis of randomized controlled trials. The main Mendelian randomization analyses showed that every 1-SD...
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