Article

Urate, blood pressure and cardiovascular disease: updated evidence from Mendelian randomization and meta-analysis of clinical trials

2019-12-15

Abstract excerpt

<h4>Aims</h4> To investigate the effect of serum urate on blood pressure and cardiovascular disease (CVD) risk by updating evidence from Mendelian randomization (MR) analysis and meta-analysis of randomized controlled trials (RCTs). <h4>Methods and Results</h4> Using recently available data from the Million Veterans Program and UK Biobank, the main MR analyses showed that every 1-standard deviation increase in gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f367041-04b4-527a-985d-ceed07fa5634
DOI: 10.1101/2019.12.11.19014472

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Urate, blood pressure and cardiovascular disease: updated evidence from Mendelian randomization and meta-analysis of clinical trialsDOI 10.1101/2019.12.11.19014472Read

Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.Semantic proximity Read

Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian RandomizationSemantic proximity Read

A Phenome-wide Mendelian Randomisation study on genetically determined serum urate levels in UK Biobank cohortSemantic proximity Read

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysisSemantic proximity Read

Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization studySemantic proximity Read

Sex-specific effect of serum urate levels on coronary heart disease and myocardial infarction prevention: A Mendelian randomization study.Semantic proximity Read

Urinary biomarkers and cardiovascular outcomes in the UK Biobank: observational and Mendelian randomization analysesSemantic proximity Read

Sodium intake and the risk of various types of cardiovascular diseases: a Mendelian randomization studySemantic proximity Read

Causal relationship between serum uric acid and cardiovascular disease: a Mendelian randomization studySemantic proximity Read

Genetic susceptibility to uric acid and selected cardiovascular outcomes: a systematic review and meta-analysis of Mendelian randomization studies.Semantic proximity Read

Causal relationship between serum uric acid and cardiovascular disease: A Mendelian randomization studySemantic proximity Read

Serum urate, cardiovascular mediators, and atrial fibrillation: genetic evidence for URAT1-targeted therapy.Semantic proximity Read