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Genetic susceptibility to uric acid and selected cardiovascular outcomes: a systematic review and meta-analysis of Mendelian randomization studies.

Frontiers in endocrinology - 1 Jan 2026

Li Chunping, Chen Ping, Zheng Fangda

Abstract excerpt

Background: Serum urate has been associated with cardiovascular disease in observational studies, but whether genetically predicted higher serum urate levels contribute to specific cardiovascular outcomes remains uncertain. We conducted a systematic review and meta-analysis of Mendelian randomization (MR) studies evaluating serum urate-, hyperuricemia-, or gout-related genetic susceptibility in relation to...

Topics

Humans
Mendelian Randomization Analysis
Uric Acid
Cardiovascular Diseases
Genetic Predisposition to Disease
Hyperuricemia
Gout
Genome-Wide Association Study

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 42568465
DOI: 10.3389/fendo.2026.1880061
PMCID: PMC13447163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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