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CRISPR Interference (CRISPRi) and CRISPR Activation (CRISPRa) to Explore the Oncogenic lncRNA Network.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Morelli Eugenio, Gulla' Annamaria, Amodio Nicola, Taiana Elisa, Neri Antonino, Fulciniti Mariateresa, Munshi Nikhil C

Abstract excerpt

The human genome contains thousands of long noncoding RNAs (lncRNAs), even outnumbering protein-coding genes. These molecules can play a pivotal role in the development and progression of human disease, including cancer, and are susceptible to therapeutic intervention. Evidence of biologic function, however, is still missing for the vast majority of them. Both loss-of-function (LOF) and gain-of-function (GOF)...

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PMID: 34160808
DOI: 10.1007/978-1-0716-1581-2_13

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