Article
Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jun 2002
Zheng Huiyuan, Corkern Michele M, Crousillac Scott M, Patterson Laurel M, Phifer Curtis B, Berthoud Hans-Rudolf
Abstract excerpt
Agouti-related protein (AgRP) is coexpressed with neuropeptide Y (NPY) in a population of neurons in the arcuate nucleus (ARC) of the hypothalamus and stimulates food intake for up to 7 days if injected intracerebroventricularly. The prolonged food intake stimulation does not seem to depend on continued competition at the melanocortin-4 receptor (MC4R), because the relatively specific MC4R agonist MTII regains...
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