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Article

Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas.

Nature microbiology - 1 Jan 2026

Bosch Barbara, Munsamy-Govender Vanisha, Sarathy Jansy, Lilic Mirjana, Olinares Paul Dominic B, Eckartt Kathryn A, Nalam Pranav, Lang Markus, Simon Marcell, Richter Adrian, Rock Jeremy M, Campbell Elizabeth A

Abstract excerpt

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, remains the deadliest human pathogen. Treatment is hampered by drug resistance and the persistence of slow-growing or non-replicating populations. Rifampicin, a cornerstone of first-line therapy, inhibits transcription during promoter escape, but resistance mutations undermine efficacy and drive resistance spread. We revisited the...

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Antitubercular Agents
DNA-Directed RNA Polymerases
Drug Resistance, Bacterial
Granuloma
Mycobacterium tuberculosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41339746
DOI: 10.1038/s41564-025-02201-6
PMCID: PMC12858399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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