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Article

Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.

Chemistry & biology - 29 May 2009

Barkan Daniel, Liu Zhen, Sacchettini James C, Glickman Michael S

Abstract excerpt

Mycobacterium tuberculosis infection remains a major global health problem complicated by escalating rates of antibiotic resistance. Despite the established role of mycolic acid cyclopropane modification in pathogenesis, the feasibility of targeting this enzyme family for antibiotic development is unknown. We show through genetics and chemical biology that mycolic acid methyltransferases are essential for M....

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Identifiers

PMID: 19477414
DOI: 10.1016/j.chembiol.2009.04.001
PMCID: PMC2731493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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