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Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

23 Jun 2020

Abstract excerpt

Efforts at host-directed therapy of tuberculosis have produced little control of the disease in experimental animals to date. This is not surprising, given that few specific host targets have been validated, and reciprocally, many of the compounds tested potentially impact multiple targets with both beneficial and detrimental consequences. This puts a premium on identifying appropriate molecular targets and...

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PMID: 32574211
DOI: 10.1371/journal.ppat.1008567

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