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Article

Population Pharmacokinetics of Intravenous Methadone Enantiomers in Adults: A Comprehensive Model.

Clinical pharmacology and therapeutics - 1 Mar 2026

Henthorn Thomas K, Kharasch Evan D

Abstract excerpt

Methadone is a utilitarian opioid with growing use for anesthesia and postoperative pain. Methadone pharmacokinetic models have evolved over time; however, there is no comprehensive population pharmacokinetic model. This investigation developed a population model for R(-)- and S(+)-enantiomers of methadone and the primary metabolite 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in plasma and urine,...

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Topics

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Share to Administration, Intravenous
Share to Analgesics, Opioid
Share to Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Methadone

Share to Models, Biological

Share to Pyrrolidines

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Source

Identifiers

PMID: 41321181
DOI: 10.1002/cpt.70147

Genes

CYP2B6
CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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