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Article

Ethnic and genetic factors in methadone pharmacokinetics: a population pharmacokinetic study.

Drug and alcohol dependence - 1 Dec 2014

Bart Gavin, Lenz Scott, Straka Robert J, Brundage Richard C

Abstract excerpt

BACKGROUND: Treatment of opiate use disorders with methadone is complicated by wide interindividual variability in pharmacokinetics. To identify potentially contributing covariates in methadone pharmacokinetics, we used population pharmacokinetic modeling to estimate clearance (CL/F) and volume of distribution (V/F) for each methadone enantiomer in an ethnically diverse methadone maintained population. METHODS:...

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Source

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Identifiers

PMID: 25456329
DOI: 10.1016/j.drugalcdep.2014.10.014
PMCID: PMC4254688

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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