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Article

Exploring the Population Pharmacokinetic and Pharmacogenetics Characteristics of Flurbiprofen Isomers in Selective Joint Replacement Patients with Postoperative Pain.

Drug design, development and therapy - 1 Jan 2025

Yao Han, Luo Xingxian, Yuan Jinjie, Zhang Hong, An Haiyan, Feng Yi

Abstract excerpt

Purpose: Flurbiprofen plays a critical role in clinical pain management. This study aims to elucidate the population pharmacokinetic (PPK) profiles of flurbiprofen's enantiomers, R(-) and S(+)-flurbiprofen in human subjects, following intravenous administration, while investigating the influence of clinical covariates. Patients and Methods: PPK modeling of flurbiprofen isomers was based on a prospective study...

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Topics

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Share to Administration, Intravenous
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anti-Inflammatory Agents, Non-Steroidal

Share to ATP Binding Cassette Transporter, Subfamily B

Share to Cytochrome P-450 CYP2C9

Share to Pharmacogenetics

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Share to Stereoisomerism

Source

Open in PubMed Open full text

Identifiers

PMID: 41090024
DOI: 10.2147/DDDT.S542722
PMCID: PMC12517301

Genes

ABCB1
POR
CYP2C9
UGT1A9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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