Article
Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.
International journal of clinical pharmacology and therapeutics - 1 Jul 2007
Coller J K, Joergensen C, Foster D J R, James H, Gillis D, Christrup L, Somogyi A A
Abstract excerpt
OBJECTIVE: To investigate the influence of CYP2D6 genotype on the oral clearance of (R)-, (S)- and rac-methadone. METHODS: In this retrospective study, CYP2D6 genotypes were identified in 56 methadone maintained subjects. Plasma concentrations of (R)-, (S)- and rac-methadone were determined by stereoselective HPLC and sufficient data were available to estimate the apparent oral clearances of (R)-, (S)- and...
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