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Article

Pharmacokinetics and pharmacodynamics of methadone enantiomers after a single oral dose of racemate.

Clinical pharmacology and therapeutics - 1 Jul 2001

Boulton D W, Arnaud P, DeVane C L

Abstract excerpt

BACKGROUND: The pharmacokinetics and dynamics of methadone are characterized by high interindividual variability. This study aimed to examine a number of factors that may contribute to this variability. METHODS: Eight healthy drug-free women were administered 0.2 mg/kg of R,S-methadone orally. The concentrations of methadone's enantiomers in plasma and urine were monitored for 96 hours. Vital signs, blood...

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Source

Identifiers

PMID: 11452244
DOI: 10.1067/mcp.2001.116793

Genes

ORM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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