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Article

CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer.

Journal of clinical psychopharmacology - 1 Aug 2011

Wang Sheng-Chang, Ho Ing-Kang, Tsou Hsiao-Hui, Tian Jia-Ni, Hsiao Chin-Fu, Chen Chia-Hui, Tan Happy Kuy-Lok, Lin Linen, Wu Chi-Shin, Su Lien-Wen, Huang Chieh-Liang, Yang Yi-Hong, Liu Ming-Lun, Lin Keh-Ming, Chen Chun-Yu, Liu Shu Chih, Wu Hsiao-Yu, Chan Hsiu-Wen, Tsai Ming-Hsien, Lin Pei-Sheng, Liu Yu-Li

Abstract excerpt

Methadone is a racemic compound composed of the R-form and S-form enantiomers. The drug is usually used in maintenance therapy for the heroin-addicted patients. In our previous study, we found that the cytochrome P-450 (CYP) isozyme 2B6 preferentially metabolizes the S-methadone enantiomer. We thus tested whether CYP2B6 gene polymorphisms had any influence on the concentration or clearance of methadone. Ten...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21694616
DOI: 10.1097/JCP.0b013e318222b5dd

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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