Article
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy.
Clinical pharmacology and therapeutics - 1 Oct 2024
Robinson Katherine M, Eum Seenae, Desta Zeruesenay, Tyndale Rachel F, Gaedigk Andrea, Crist Richard C, Haidar Cyrine E, Myers Alan L, Samer Caroline F, Somogyi Andrew A, Zubiaur Pablo, Iwuchukwu Otito F, Whirl-Carrillo Michelle, Klein Teri E, Caudle Kelly E, Donnelly Roseann S, Kharasch Evan D
Abstract excerpt
Methadone is a mu (μ) opioid receptor agonist used clinically in adults and children to manage opioid use disorder, neonatal abstinence syndrome, and acute and chronic pain. It is typically marketed as a racemic mixture of R- and S-enantiomers. R-methadone has 30-to 50-fold higher analgesic potency than S-methadone, and S-methadone has a greater adverse effect (prolongation) on the cardiac QTc interval. Methadone...
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