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Article

Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.

Anesthesiology - 1 Nov 2015

Kharasch Evan D, Regina Karen J, Blood Jane, Friedel Christina

Abstract excerpt

BACKGROUND: Interindividual variability in methadone disposition remains unexplained, and methadone accidental overdose in pain therapy is a significant public health problem. Cytochrome P4502B6 (CYP2B6) is the principle determinant of clinical methadone elimination. The CYP2B6 gene is highly polymorphic, with several variant alleles. CYP2B6.6, the protein encoded by the CYP2B6*6 polymorphism, deficiently...

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Share to Analgesics, Opioid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Clearance Rate

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 26389554
DOI: 10.1097/ALN.0000000000000867
PMCID: PMC4667947

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