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Article

Loss of LafB activity reverses daptomycin resistance in E. faecium.

mBio - 14 Jan 2026

Scarpa de Mello Suelen, Schultz Bailey, Goh Byoungsook, Grote Alexandra, Shea Terrance, Muscato Jacob, Oh Sungwhan F, Manson Abigail L, Earl Ashlee M, Walker Suzanne, Camargo Ilana L B C, Gilmore Michael S

Abstract excerpt

Infections caused by multidrug-resistant enterococci, particularly vancomycin-resistant Enterococcus (VRE), present significant therapeutic challenges. Daptomycin, a last-line treatment for VRE, often loses efficacy due to the emergence of resistance. In this study, we revealed the critical role of the lafB gene as a key determinant of daptomycin susceptibility and resistance in E. faecium. We showed that in the...

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Anti-Bacterial Agents
Bacterial Proteins
Daptomycin
Drug Resistance, Bacterial
Enterococcus faecium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gram-Positive Bacterial Infections

Microbial Sensitivity Tests

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Identifiers

PMID: 41313008
DOI: 10.1128/mbio.00715-25
PMCID: PMC12802148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Loss of LafB activity reverses daptomycin resistance in E. faecium.PMID 41313008Read ↗

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