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Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate.

Antimicrobial agents and chemotherapy - 6 May 2026

Sánchez-Osuna Miquel, Bierge Paula, Gómez-Sánchez Inmaculada, Guitart-Matas Judith, Monsálvez Víctor, Rabanal Patricia, Pereira Ana P, Freitas Ana R, Peixe Luisa, Espasa Mateu, Gasch Oriol, Novais Carla, Pich Oscar Q

Abstract excerpt

Enterococcus faecium exhibits intrinsic resistance to cephalosporins (CPHs), yet the genetic determinants of this phenotype remain incompletely understood. To date, E. faecium strains with low minimum inhibitory concentrations (MICs) of CPH have only been described following genetic manipulation. At Parc Taulí University Hospital, we identified a clinical isolate of ampicillin-susceptible E. faecium (Efm5) that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41870094
DOI: 10.1128/aac.01948-25
PMCID: PMC13148053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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