Article
Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation.
PloS one - 1 Jan 2012
Wilkerson Matthew D, Yin Xiaoying, Walter Vonn, Zhao Ni, Cabanski Christopher R, Hayward Michele C, Miller C Ryan, Socinski Mark A, Parsons Alden M, Thorne Leigh B, Haithcock Benjamin E, Veeramachaneni Nirmal K, Funkhouser William K, Randell Scott H, Bernard Philip S, Perou Charles M, Hayes D Neil
Abstract excerpt
BACKGROUND: Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic molecular subtypes are a validated stratification of naturally-occurring gene expression patterns and encompass different functional pathways and patient outcomes. Patients may have incurred different mutations and...
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