Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.

doi:10.1371/journal.pmed.1002162

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Article

Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.

PLoS medicine - 1 Dec 2016

Shi Jianxin, Hua Xing, Zhu Bin, Ravichandran Sarangan, Wang Mingyi, Nguyen Cu, Brodie Seth A, Palleschi Alessandro, Alloisio Marco, Pariscenti Gianluca, Jones Kristine, Zhou Weiyin, Bouk Aaron J, Boland Joseph, Hicks Belynda, Risch Adam, Bennett Hunter, Luke Brian T, Song Lei, Duan Jubao, Liu Pengyuan, Kohno Takashi, Chen Qingrong, Meerzaman Daoud, Marconett Crystal, Laird-Offringa Ite, Mills Ian, Caporaso Neil E, Gail Mitchell H, Pesatori Angela C, Consonni Dario, Bertazzi Pier Alberto, Chanock Stephen J, Landi Maria Teresa

Abstract excerpt

BACKGROUND: Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer and has a high risk of distant metastasis at every disease stage. We aimed to characterize the genomic landscape of LUAD and identify mutation signatures associated with tumor progression. METHODS AND FIND...

Topics

Adenocarcinoma
Adenocarcinoma of Lung
Adult
Aged
DNA Methylation
Exome
Female
Genomics
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Italy

Lung Neoplasms

Male

Middle Aged

Mutation

Retrospective Studies

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27923066
DOI: 10.1371/journal.pmed.1002162
PMCID: PMC5140047

Genes

EGFR
ZKSCAN1
BRAF
KEAP1
KRAS
MET
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-27923066-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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