Article

Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease

2025-10-06

Abstract excerpt

<h4> ABSTRACT </h4> Lung adenocarcinoma ( LUAD ), the most common form of lung cancer, is a heterogeneous disease with highly variable histopathologic features and clinical outcomes. LUAD premalignant lesions ( PMLs ) are localized proliferative lesions of atypical pneumocytes that proliferate along the alveolar walls. In this study, we characterized the molecular heterogeneity across PMLs, regardless of histo...

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Literature Corpus work: 18e7342d-e70a-5f59-a67b-e8d6514c51ca
DOI: 10.1101/2025.10.04.680402

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