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Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditions

2020-05-14

Abstract excerpt

Cyclin dependent kinase 5 (Cdk5) regulates various developmental and physiological processes in the central nervous system. Deregulation of Cdk5 activity in neurons induces severe neurodegeneration and has been implicated in Alzheimer’s disease (AD) and other neurodegenerative conditions. A large fraction of AD risk genes are highly expressed in microglia, highlighting an important role for these cells in AD patho...

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Literature Corpus work
3b344e14-39ab-5e8d-aace-1e67a858b2f2
DOI
10.1101/2020.05.12.090605
Open publication

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Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditionsDOI 10.1101/2020.05.12.090605
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