Article
The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity.
The Journal of cell biology - 24 Oct 2016
Li Yuan, Chen Baohui, Zou Wei, Wang Xin, Wu Yanwei, Zhao Dongfeng, Sun Yanan, Liu Yubing, Chen Lianwan, Miao Long, Yang Chonglin, Wang Xiaochen
Abstract excerpt
Lysosomes degrade macromolecules and recycle metabolites as well as being involved in diverse processes that regulate cellular homeostasis. The lysosome is limited by a single phospholipid bilayer that forms a barrier to separate the potent luminal hydrolases from other cellular constituents, thus protecting the latter from unwanted degradation. The mechanisms that maintain lysosomal membrane integrity remain...
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