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Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging in Caenorhabditis elegans

7 Jul 2017

Abstract excerpt

Abstract Reproduction and aging are intertwined. While lifespan and reproductive strategies vary greatly among animals, the progeny production period generally... Aging in eukaryotes is accompanied by widespread deterioration of the somatic tissue. Yet, abolishing germ cells delays the age-dependent somatic decline in Caenorhabditis elegans. In adult worms lacking germ cells, the activation of the DAF-9/DAF-12...

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PMID: 28696216
DOI: 10.1534/genetics.117.204222

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