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Article

Autophagy-mediated longevity is modulated by lipoprotein biogenesis

15 Dec 2015

Abstract excerpt

Autophagy-dependent longevity models in C. elegans display altered lipid storage profiles, but the contribution of lipid distribution to life-span extension is not fully understood. Here we report that lipoprotein production, autophagy and lysosomal lipolysis are linked to modulate life span in a conserved fashion. We find that overexpression of the yolk lipoprotein VIT/vitellogenin reduces the life span of...

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PMID: 26671266
DOI: 10.1080/15548627.2015.1127464

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