The Loss-of-Function S267F Variant in HBV Receptor NTCP Reduces Human Risk for HBV Infection and Disease Progression.

doi:10.1093/infdis/jiy355

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Article

The Loss-of-Function S267F Variant in HBV Receptor NTCP Reduces Human Risk for HBV Infection and Disease Progression.

The Journal of infectious diseases - 22 Sept 2018

An Ping, Zeng Zheng, Winkler Cheryl A

Abstract excerpt

Background: Sodium taurocholate cotransporting polypeptide (NTCP, SLC10A1) is a hepatocyte receptor for hepatitis B virus (HBV) infection. The natural NTCP S267F variant causes loss of NTCP HBV receptor function. We assessed the association of S267F with HBV resistance, HBV infection clearance, and HBV-related cirrhosis and hepatocellular carcinoma (HCC). Methods: We tested the effects of S267F in 1117 Han...

Topics

Asian People
Disease Progression
Female
Genetic Variation
Genotype
Hepatitis B
Hepatitis B virus
Humans
Male
Middle Aged
Organic Anion Transporters, Sodium-Dependent
Symporters

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Identifiers

PMID: 29905807
DOI: 10.1093/infdis/jiy355
PMCID: PMC6151084

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