Article
Effect of S267F variant of NTCP on the patients with chronic hepatitis B.
Scientific reports - 15 Dec 2017
Lee Hye Won, Park Hye Jung, Jin Bora, Dezhbord Mehrangiz, Kim Do Young, Han Kwang-Hyub, Ryu Wang-Shick, Kim Seungtaek, Ahn Sang Hoon
Abstract excerpt
Sodium taurocholate cotransporting polypeptide (NTCP) was identified as an entry receptor for hepatitis B virus (HBV) infection. The substitution of serine at position 267 of NTCP with phenylalanine (S267F) is an Asian-specific variation that hampers HBV entry in vitro. In this study, we aimed to evaluate the prevalence of S267F polymorphism in Korean patients with chronic hepatitis B (CHB) and its association...
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