Association of the S267F variant on NTCP gene and treatment response to pegylated interferon in patients with chronic hepatitis B: a multicentre study.

doi:10.3851/IMP3179

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Article

Association of the S267F variant on NTCP gene and treatment response to pegylated interferon in patients with chronic hepatitis B: a multicentre study.

Antiviral therapy - 1 Jan 2018

Thanapirom Kessarin, Suksawatamnuay Sirinporn, Sukeepaisarnjaroen Wattana, Treeprasertsuk Sombat, Tanwandee Tawesak, Charatcharoenwitthaya Phunchai, Thongsawat Satawat, Leerapun Apinya, Piratvisuth Teerha, Boonsirichan Rattana, Bunchorntavakul Chalermrat, Pattanasirigool Chaowalit, Pornthisarn Bubpha, Tuntipanichteerakul Supoj, Sripariwuth Ekawee, Jeamsripong Woramon, Sanpajit Theeranun, Poovorawan Yong, Komolmit Piyawat

Abstract excerpt

BACKGROUND: Sodium taurocholate co-transporting polypeptide (NTCP) is a cell receptor for HBV. The S267F variant on the NTCP gene is inversely associated with the chronicity of HBV infection, progression to cirrhosis and hepatocellular carcinoma in East Asian populations. The aim of this study was to determine whether the S267F variant was associated with response to pegylated interferon (PEG-IFN) in patients...

Topics

Adult
Alleles
Amino Acid Substitution
Antiviral Agents
Biomarkers
Drug Therapy, Combination
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis B virus

Hepatitis B, Chronic

Humans

Interferon-alpha

Male

Middle Aged

Organic Anion Transporters, Sodium-Dependent

Pharmacogenomic Variants

Symporters

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 28635613
DOI: 10.3851/IMP3179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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