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Article

Mendelian randomization facilitates identification of schizophrenia risk enhancer RNAs.

Molecular psychiatry - 1 Apr 2026

Ye Linyan, Ni Chaoying, Chen Renhao, Che Siyao, Xiong Fu, Zhao Cunyou, Wang Zhongju

Abstract excerpt

The transcription of enhancer RNA (eRNA) marks enhancer activity and may confer context-dependent regulatory functions, yet its underlying mechanism remains elusive. Leveraging BrainSeq data, we constructed ancestry-stratified expression quantitative trait locus (eQTL) maps for 71,022 transcriptional non-coding enhancer (TNE) RNAs. By integrating the latest Psychiatric Genomics Consortium (PGC3) schizophrenia...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41276612
DOI: 10.1038/s41380-025-03358-6
PMCID: PMC12999466

Genes

RGS6
ZNF135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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