Article

Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants

2022-09-17

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified 145 genomic regions that contribute to schizophrenia risk, but linkage disequilibrium (LD) makes it challenging to discern causal variants. Computational finemapping prioritized thousands of credible variants, ∼98% of which lie within poorly characterized non-coding regions. To functionally validate their regulatory effects, we performed a massive...

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Literature Corpus work: 742683f7-927a-5089-b331-da0e0f0490fd
DOI: 10.1101/2022.09.15.22279954

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