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Article

Functional variants at 1p36.23 confer risk of schizophrenia through modulating RERE.

Nature communications - 24 Jan 2026

Liu Yixing, Wang Junyang, Yang Hong, Li Yifan, Mu Changgai, Dang Xinglun, Chen Xinran, Li Danyang, Li Mingna, Liu Jiewei, Li Shiwu, Yang Jinfeng, Chen Xi, Zhang Chen, Feng Jin, Luo Xiong-Jian

Abstract excerpt

Genome-wide association studies have identified 1p36.23 as a schizophrenia risk locus. However, the functional variants and genes driving the association remain unknown. Here, we identified two functional variants (i.e., rs159961 and rs301792) at the 1p36.23 risk locus. Both variants reside introns of RERE and exhibit allele-specific enhancer activity. Risk alleles of rs159961 and rs301792 increase enhancer...

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Share to Chromosomes, Human, Pair 1
Share to Dendritic Spines
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Share to Receptors, N-Methyl-D-Aspartate
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Source

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Identifiers

PMID: 41580391
DOI: 10.1038/s41467-026-68449-6
PMCID: PMC12914037

Genes

POLR2A
RARB
REST
RXRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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