Article
Understanding the genetic liability to schizophrenia through the neuroepigenome.
Schizophrenia research - 1 Nov 2016
Fullard John F, Halene Tobias B, Giambartolomei Claudia, Haroutunian Vahram, Akbarian Schahram, Roussos Panos
Abstract excerpt
The Psychiatric Genomics Consortium-Schizophrenia Workgroup (PGC-SCZ) recently identified 108 loci associated with increased risk for schizophrenia (SCZ). The vast majority of these variants reside within non-coding sequences of the genome and are predicted to exert their effects by affecting the mechanism of action of cis regulatory elements (CREs), such as promoters and enhancers. Although a number of...
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