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Article

Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro.

Fluids and barriers of the CNS - 7 Jan 2021

Raut Snehal, Patel Ronak, Al-Ahmad Abraham J

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the most common form of neurodegenerative disease. It is an irreversible condition marked by irreversible cognitive loss, commonly attributed to the loss of hippocampal neurons due to the formation of senile plaques and neurofibrillary tangles. Although the sporadic form is the most prevalent, the presence of familial form (involving several genes such as APP, PSEN1, and...

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Identifiers

PMID: 33413468
DOI: 10.1186/s12987-020-00235-y
PMCID: PMC7789219

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