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Article

ML-MAGES enables multivariate genetic association analyses with genes and effect size shrinkage.

Genome research - 3 Dec 2025

Liu Xiran, Crawford Lorin, Ramachandran Sohini

Abstract excerpt

A fundamental goal of genetics is to identify which and how genetic variants are associated with a trait, often using the regression results from genome-wide association (GWA) studies. Important methodological challenges account for inflation in GWA effect estimates as well as in investigating more than one trait simultaneously. We leverage machine learning approaches for these two challenges, developing a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41260926
DOI: 10.1101/gr.280440.125
PMCID: PMC12667714

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