Article

Bayesian Multivariate Genetic Analysis Boosts Translational Insights

2022-02-15

Abstract excerpt

<title>Abstract</title> <p>Conventional genome-wide association studies interrogate individual variants against individual traits. We introduce a multivariate adaptive shrinkage (mash) model that allows each variant to be modeled as a mixture of multivariate normal distributions, boosting power when genetic effects across conditions are shared, using summary statistics. We show that controlling local false sign r...

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Literature Corpus work: 287a2baf-668d-5afc-afc7-12ee0a274d75
DOI: 10.21203/rs.3.rs-1319235/v1

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