Article
Reliable variability in subjective responses to parenteral hydromorphone administration: empirical confirmation of an opioid non-responder phenotype.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2026
Ellis Jennifer D, Towers Eleanor Blair, Dunn Kelly E, Tsang Siny, Speed Traci, Lerman Sheera F, Mei Michelle, Lynch Wendy, Strain Eric C, Smith Michael T, Finan Patrick H
Abstract excerpt
A subset of individuals without a history of prolonged or problematic opioid use demonstrate attenuated subjective responses to orally administered opioids despite physiological and analgesic responses. This phenotype may confer elevated risk for greater analgesic requests and physiologic dependence, but it is unclear if this is driven by differences in route of administration. This study evaluated responses to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.