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Article

Polymorphisms in the A118G SNP of the OPRM1 gene produce different experiences of opioids: A human laboratory phenotype-genotype assessment.

Addiction biology - 1 Jan 2024

Dunn Kelly E, Huhn Andrew S, Finan Patrick H, Mange Ami, Bergeria Cecilia L, Maher Brion S, Rabinowitz Jill A, Strain Eric C, Antoine Denis

Abstract excerpt

Allelic variations in the A118G SNP of the OPRM1 gene change opioid signaling; however, evaluations of how allelic differences may influence opioid effects are lacking. This human laboratory paradigm examined whether the AA versus AG/GG genotypes determined opioid response profiles. Individuals with limited opioid exposure (N = 100) completed a five-day within-subject, double-blind, placebo-controlled,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 38221808
DOI: 10.1111/adb.13355
PMCID: PMC10898793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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