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Article

Inter-individual divergence in thresholds for detecting opioid effects: Within-subject human laboratory evidence of a testable behavioral phenotype.

Drug and alcohol dependence - 1 Jun 2025

McKendrick Greer, Durgin Caitlyn J, Huhn Andrew S, Bergeria Cecilia L, Finan Patrick H, Antoine Denis, Dunn Kelly E

Abstract excerpt

Variations in inter-individual response to opioid medications has not been well-investigated in prospective, empirical designs or in persons who have no learned experience with opioids or current pain conditions. These analyses categorized response to opioids during rigorous human laboratory experimental conditions. Healthy individuals (N = 75) with little to no prior opioid exposure completed a 5-day residential...

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Identifiers

PMID: 40086371
DOI: 10.1016/j.drugalcdep.2025.112644
PMCID: PMC13411458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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