Article
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations.
Pain - 1 Sept 2016
Edwards Robert R, Dworkin Robert H, Turk Dennis C, Angst Martin S, Dionne Raymond, Freeman Roy, Hansson Per, Haroutounian Simon, Arendt-Nielsen Lars, Attal Nadine, Baron Ralf, Brell Joanna, Bujanover Shay, Burke Laurie B, Carr Daniel, Chappell Amy S, Cowan Penney, Etropolski Mila, Fillingim Roger B, Gewandter Jennifer S, Katz Nathaniel P, Kopecky Ernest A, Markman John D, Nomikos George, Porter Linda, Rappaport Bob A, Rice Andrew S C, Scavone Joseph M, Scholz Joachim, Simon Lee S, Smith Shannon M, Tobias Jeffrey, Tockarshewsky Tina, Veasley Christine, Versavel Mark, Wasan Ajay D, Wen Warren, Yarnitsky David
Abstract excerpt
There is tremendous interpatient variability in the response to analgesic therapy (even for efficacious treatments), which can be the source of great frustration in clinical practice. This has led to calls for "precision medicine" or personalized pain therapeutics (ie, empirically based algorithms that determine the optimal treatments, or treatment combinations, for individual patients) that would presumably...
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