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Landscape of Exhausted T Cells in Tuberculosis Revealed by Single-Cell Sequencing

14 Mar 2023

Abstract excerpt

Identifying the changes in immune cells in response to infection can provide a better understanding of the effects of Mycobacterium tuberculosis on the host immune system. We performed single-cell RNA-sequencing analysis of CD4 + T and CD8 + T cells isolated from peripheral blood mononuclear cells of healthy individuals and patients with tuberculosis to reveal the cellular characteristics.

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PMID: 36916943
DOI: 10.1128/spectrum.02839-22

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