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Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection

6 May 2015

Abstract excerpt

The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors that affect immunodominance are incompletely understood. Whether immunodominant epitopes elicit protective CD8+ T cell responses or instead act as decoys to subvert immunity and allow pathogens...

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PMID: 25945999
DOI: 10.1371/journal.ppat.1004849

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