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Article

Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals.

Scientific reports - 16 Jun 2017

Miyama Takahiko, Kawase Takakazu, Kitaura Kazutaka, Chishaki Ren, Shibata Masashi, Oshima Kumi, Hamana Hiroshi, Kishi Hiroyuki, Muraguchi Atsushi, Kuzushima Kiyotaka, Saji Hiroh, Shin-I Tadasu, Suzuki Ryuji, Ichinohe Tatsuo

Abstract excerpt

To expand our knowledge of the ontogeny of the T-cell receptor (TCR) repertoire of antigen-specific T-cell subsets, we combined next-generation deep sequencing and single-cell multiplex clonotype analysis to evaluate the diversity and frequency of paired TCRs, their functions and whether clonotypic TCRs are shared among different individuals. Using an HLA-A*02-restricted cytomegalovirus (CMV) pp65-derived...

Read the complete abstract on PubMed

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Share to Immunity, Cellular
Share to Immunologic Memory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunophenotyping

Share to Lymphocyte Activation

Share to Receptors, Antigen, T-Cell

Share to T-Cell Antigen Receptor Specificity

Share to Transduction, Genetic

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Source

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Identifiers

PMID: 28623251
DOI: 10.1038/s41598-017-03855-x
PMCID: PMC5473819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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