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Article

"Oxygen tone" drives stage-specific OPC phenotypes for cell-based stroke therapy.

Stem cell reports - 11 Nov 2025

Kokaia Zaal, Palma-Tortosa Sara

Abstract excerpt

Oligodendrocyte precursor cells (OPCs) display functional plasticity beyond myelination. Kuwata et al. explore how hypoxia shapes OPC features after ischemic stroke. Combining single-cell transcriptomics with in vivo and ex vivo models, they reveal oxygen-dependent OPC phenotypes promoting angiogenesis and remyelination, highlighting OPC versatility and potential for novel stroke cell therapies.

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Identifiers

PMID: 41223837
DOI: 10.1016/j.stemcr.2025.102709
PMCID: PMC12790716

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