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Article

X-box binding protein 1 as a key modulator in "healing endothelial cells", a novel EC phenotype promoting angiogenesis after MCAO.

Cellular & molecular biology letters - 8 Nov 2022

Chen Zhuohui, Wang Xiang, Wu Haiyue, Fan Yishu, Yan Zhouyi, Lu Chenxiao, Ouyang Hongfei, Zhang Shiyu, Zhang Mengqi

Abstract excerpt

BACKGROUND: Endothelial cells (ECs) play an important role in angiogenesis and vascular reconstruction in the pathophysiology of ischemic stroke. Previous investigations have provided a profound cerebral vascular atlas under physiological conditions, but have failed to identify new disease-related cell subtypes. We aimed to identify new EC subtypes and determine the key modulator genes. METHODS: Two datasets...

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Share to Endothelial Cells
Share to Infarction, Middle Cerebral Artery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36348288
DOI: 10.1186/s11658-022-00399-5
PMCID: PMC9644469

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