Article

Non-Canonical Targets of HIF1a Drive Cell-Type-Specific Dysfunction

2020-04-04

Abstract excerpt

<h4>SUMMARY</h4> All mammalian cells sense and respond to insufficient oxygen, or hypoxia, through the activity of hypoxia-inducible factors (HIFs), an evolutionarily conserved family of transcriptional regulators that promote oxygen-independent energy metabolism and angiogenesis. While HIF activation is transiently protective for all cells, prolonged HIF activity drives distinct pathological responses in differe...

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Literature Corpus work: 4e30ce1e-9031-5314-833d-ab9b21105517
DOI: 10.1101/2020.04.03.003632

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